Neuregulin 2 is a member of growth and differentiation factors that is mapped to chromosome 5q31.2 which contains 12 exons and span about 180kb where its genomic structure is similar to neuregulin 1. It is also revealed to exists in two isoform such as neuregulin 2-alpha and neuregulin 2-beta.
Neuregulin 2 is highly express in cerebellum that is thought to interact with ERBB family receptors for growth and differentiation factors. The products of these genes arbitrate distinct biological processes by substituting at special sites in tissue thus, eliciting different biological responses incells.
Neuregulin 2 plays an essential role in regulating the proliferation and differentiation of Schwann cells, the myelin cells in the peripheral nervous system. It also exhibits a distinct expression pattern in adult brain and developing heart.
Gene name: NRG2
Protein name: Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2)