Confused and have questions? We’ve got answers. With Chegg Study, you can get step-by-step solutions to your questions from an expert in the field. If you rather get 1:1 study help, try 30 minutes of free online tutoring with Chegg Tutors.

Neprilysin

From Biology-Online Dictionary | Biology-Online Dictionary
Jump to: navigation, search

neprilysin

(Science: enzyme) enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyses cleavage at the amino group of hydrophobic residues of the b-chain of insulin as well as opioid peptides and other biologically active peptides.

The enzyme is inhibited primarily by edta, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukaemia antigen (calla), an important marker in the diagnosis of human acute lymphocytic leukaemia.

Registry number: EC 3.4.24.11