Myocyte enhancer factor 2A
Myocyte enhancer factor 2A gene is mapped on chromosome 15q26.3 that contain several alternative splice variants predicted to encode differentprotein products which may involved in the induction of muscle differentiation. It is spotted at the nuclei of skeletal and cardiac muscle cells and highly expressed in heart as well as in somites during embryogenesis wherein absence of MEF2A damage the cardiac contractility resulting in sarcomere assemblage deficiency. It is also a regulatory sites phosphorylated by p38.
Myocyte enhancer factor 2A involved in the activation of several growth factors and stress induced genes in which it mediates broad range of fundamental cellular functions in cardiac and skeletal muscle development as well as in neuronal differentiation and endurance, thereby it is important in the control of cell survival, growth and apoptosis.
Myocyte enhancer factor 2A causes an autosomal dominant form ofcoronary artery disease and shows expression as a key transcriptional factor involved in cardiomyocytes function and dysfunction thereby takes part in upholding of cyto-architectural reliability in post natal cardiac myocytes.
Gene name: MEF2A
Protein name: Myocyte-specific enhancer factor 2A