Myelin-associated glycoprotein gene is mapped on chromosome 19q13.12 with a molecular weight of 100kD wherein 30% is carbohydrates and generally accepted as a member of immunoglobulin gene superfamily where it serves as a functional ligand of the NOGO-66 receptor. It is a glycoprotein specific to Schwann cells that creates myelin for the nerve cells in the nervous system functions in early development and continues in mature organisms signifying that it is not only associated with formation but maintenance as well.
Myelin-associated glycoprotein is measured as significant to the initiation and progression of myelination as well as reveals evidence to inhibit axonal regeneration showing the possibility as a ligand to regulate axonal properties. It is also associated in the mediation of interactions between neurons and oligodendrocytes throughout the development of myelin sheath where it is primarily phosphorylated at serine, threonine and tyrosine residues thereby signifies that MAG is physiologically vital in regulating oligodendrocytes-neuron interactions.
Myelin-associated glycoprotein deficiency shows sensory and muscular symptoms that indicates sensory loss in various extremities alongside with gentle to moderate muscle failing that normally begins in the toes and fingers. On severe cases as symptoms progresses implicate more damage to myelin sheaths in the nervous system resulting to the complete sensory loss on limbs and extensive muscle atrophy.
Gene name: MAG
Protein name: Myelin-associated glycoprotein