A non-tuberculous fast growing and saprophytic bacterium that is normally non-pathogenic which is rarely been associated with disease in humans.
Mycobacterium phlei is an acid-fast bacterium that containsmycolic acids which makes them the hardest bacteria to neutralize. Its genome sequence consists of 5,435 coding sequence with four sets of rRNA operons and 50tRNA encoding genes. It has a distinct genome characteristic where it encodes a putative mammalian cell entry operons which is also present among slow-growing mycobacteria that has the ability to invade and survive inside host cells including HeLa cells and macrophages.
Mycobacterium phlei is predominantly distributed in dust and soil as well as on plants. It occasionally caused disease on individuals with suppressed or weakened immune system including with arthritis, urethritis and conjunctivitis. It is associated with in treatment of asthma in adults where it must be inhaled to a certain extent to improve asthma symptoms which lessens the needs for medication and reduces acute exacerbation.
Mycobacterium phlei growth in media culture has been particularly studied for the information concerning the growth requirements of the pathogenic acid-fast bacteria since this bacterium is not pathogenic it can easily studied in the laboratory. It grows in acid hydrolyzate containing glucose, casein,minerals and aqueous infusion of beef heart.
Species: Mycobacterium phlei