Mycobacterium lepraemurium is normally found in liver, spleen and bone marrow where there is an enormous buildup of heavily infected macrophages which may upshot the local reproduction of resident macrophages or from the recruitment of blood monocytes thus, its presence in hematopoietic tissue has an express outcome on hematopoietic progenitors as well as on the composition of the peripheral blood.
Mycobacterium lepraemurium is implicated in leprosy disease in rodents including mice rats and cats but not in humans or other species that basically affects the skin, viscera and peripheral nerves. Its infection in mice creates chronic lethal disease typified by massive accumulation of macrophages throughout the mononuclear-phagocyte system.
Mycobacterium lepraemurium infects in feline manifested by ulcerated subcutaneous nodules on the commisures of its mouth in which lesion consists of granulomas containing foamy macrophages. A recent study reveals that recombinant interleukin-2 significantly reduced the total bacterial counts in the lymph nodes, liver and footpad of infected mice in which after 6 months a smaller number viable in the spleen thus, interleukin-2 limits the bacterial growth.
Species: Mycobacterium lepraemurium