Monocarboxylate transporter 1
Monocarboxylate transporter 1 gene is mapped on chromosome 1p13.2 that functions as monocarboxylate transporter with many alternative spliced variants isoforms. Its inhibition is mainly sensitive when hypoxic and obligate glycolytic where its expression is associated in chronic fatigue syndromes and psychomotor retardation.
Monocarboxylate transporter 1 is detected in blood lymphocytes and heart as well as in monocytes that catalyzed the movement of pyruvate and lactate across the plasma membrane. It is vital in metabolic manner of most tissues with distinct properties, profile and subcellular localization corresponds to specific metabolic needs such as energy metabolism in the brain, heart, skeletal muscle, tumor cells and T-lymphocytes. It also provides an essential functions in bowel movement of short chain fatty acids, spermatogenesis and drug transport.
Monocarboxylate transporter 1 gene mutation is associated in symptomatic deficiency in lactate transport (SDLT) resulted from an acidic intracellular environment created by muscle activity ensuing degeneration of muscle that releases myoglobins and creatine kinase. It reveals a good target for therapeutic intervention of glycolytic tumor cells.
Gene name: SLC16A1
Protein name: Monocarboxylate transporter 1