Monoamine Oxidase B
Monoamine Oxidase B gene encodes a 520 amino acids protein with a molecular mass of 58.8 kD that reveals 70% amino acid identity to monoamine oxidase A wherein both sequences enclosed the pentapeptide ser-gly-gly-cys-tyr, in which the required cofactor FAD is covalently bound to cysteine.
Monoamine Oxidase B degrades benzylamine and phynylethylamine as well as dopamine. It is also involved in the breakdown of neurotransmitter implicated in reinforcing and motivating behavior movement. Its inhibition is associated with enhanced activity of dopamine with decrease production of hydrogen peroxide.
Elevated monoamine oxidase B in brain is associated with Alzheimer's disease and Parkinson's disease that has been revealed to increase with age signifying the role of natural age related cognitive decline leads to increase neurological disease development later in life. Vigorous polymorphism of the monoamine oxidase B gene is linked to negative emotional stability that caused depression and stress-inducedcardiac damage.
Monoamine oxidase B active sites consists of 420 hydrophobic substrate cavity interconnected to an entrance cavity of 290 wherein recognition site for amino group is an aromatic cage formed by Try 398 and Try 435 that provides framework for catalytic mechanisms.
Gene name: MOAB
Protein name: Amine oxidase [flavin-containing] B