Migration-inhibitory factor

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migration-inhibitory factor

(Science: growth factor) A soluble, nondialysable factor that is produced by sensitised lymphocytes following exposure to a specific antigen. It inhibits macrophage migration and causes adherence.

It was originally defined on the basis of inhibition of emigration of mononuclear cells from capillary (haematocrit) tubes, more recently a 13 kD protein with migration inhibitory activity has been isolated.

Acronym: MIF

Synonym: inhibition factor.