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Michaelis-menten hypothesis

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Michaelis-Menten hypothesis

(Science: chemistry) That a complex is formed between an enzyme and its substrate (the O'Sullivan-Tompson hypothesis), which complex then decomposes to yield free enzyme and the reaction products (brown hypothesis), the latter rate determining the overall rate of substrate-product conversion.

See: michaelis-Menten constant, michaelis-Menten equation.