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noun, plural: methylprednisolones

A synthetic glucocorticoid with a chemical formula, C22H30O5, and used as steroidal anti-inflammatory agent


Methylprednisolone is one of the examples of a glucocorticoid. A glucocorticoid is a substance involved in the carbohydrate metabolism. For instance, it promotes gluconeogenesis, i.e. the metabolic process in which glucose is formed from non-carbohydrate precursors. It may be produced naturally (mainly, by the adrenal cortex) or synthetically. It exerts action to the cell by binding to the glucocorticoid receptor.

Methylprednisolone is a glucocorticoid with a chemical formula of C22H30O5. It is a synthetic glucocorticoid used to suppress the immune system. It decreases inflammation. Its pharmacological roles are as steroidal anti-inflammatory agent and antineoplastic agent. It comes in different forms. It can be administered through IV, IM, or by mouth. It is used for conditions such as rheumatic disorders, allergies, asthma, multiple sclerosis, and skin diseases. Possible side effects from long-term use are osteoporosis, easy bruising, weakness, cataracts, and increased risk to infection.

Methylprednisolone, just like other glucocorticoids, can cross cell membranes and then bind to specific receptors inside the cell to modify transcription and protein synthesis. The anti-inflammatory action is through the regulation of the biosynthesis of inflammatory mediators, e.g. prostaglandins and leukotrienes.

Chemical formula:

  • C22H30O5


  • (6α, 11β)-11,17,21-trihydroxy-6-methyl-pregna-1,4-diene-3,20-dione

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