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(Science: chemical) A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

Pharmacological action: antihypertensive agents, ganglionic blockers, nicotinic antagonists.

Chemical name: Bicyclo(2.2.1)heptan-2-amine, N,2,3,3-tetramethyl-