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Mature mRNA

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Definition

noun

The completely processed mRNA molecule in the cell of eukaryotes.


Supplement

A pre-mRNA molecule becomes a mature mRNA molecule after having undergone the following processes:

  • 5' cap addition – the addition of a 5'cap to the front or 5' end of the pre-mRNA molecule at the start of transcription
  • splicing – removal of any introns (non-coding sequences) and the splicing together of exons (protein-coding sequences)
  • editing – in some instances, the nucleotide composition is altered
  • polyadenylation – a poly a tail is added to the free 3' end at the cleavage site

Once these processes are completed the mature mRNA can then be transported from the nucleus into the cytoplasm for protein translation.


See also: pre-mRNA