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Matrix metalloproteinase-2

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The most widely expressed among Matrix Metalloproteinase that are generally found in tissues and cells that shows important role in degrading nonmatrix molecules.


Matrix metalloproteinase-2 is also identified as gelatinase that belong to the secreted group of zinc metalloproteases. It is composed ofgene that has 17kb long with 13exons varied in size from 110 to 901 bp and has 12 introns ranging from 175 to 4,350 bp located atchromosome 16q13.

Matrix metalloproteinase-2 has a critical role in the binding of progelatinase associated on the surface of angiogenic blood vessels. It is also serves as effectors of endometrial menstrual breakdown and inflammatory response that is useful in diagnosing Takayasu arthritis. It is also involved in cell migration that shows striking targets for chemotherapy.

Matrix metalloproteinase-2 are immune-reactive with antibodies directed against phosphothreonine and phosphoserine that are phosphorylated. Analyses of MMP-2 activity illustrates that the phosphorylation status significantly affects its enzymatic properties.

Matrix metalloproteinase-2 degrades extracellular matrix yet it also acts on nonmatrix substrates like in big endothelin-1, monocytes chemo-attractant protein-3, stromal derived factor and interleukin 1β precursor that expands the biological role of these important proteases.

Gene name: MMP2

Protein name: 72 kDa type IV collagenase


72 kDa gelatinase

Gelatinase A

type IV collagenase

See also:

Matrix metalloproteinase