Matrix Metalloproteinase 16
Matrix Metalloproteinase 16 consists of 604 amino acids that characterized MMP domain structure in which gene is mapped on chromosome 8q21 that has C-terminal extension holding a potential transmembrane domain akin to MMP14, MMP15 and MMP17. It is expressed as 12kb transcript in placenta, brain, heart and carcinoma cell lines but absent in kidney, lung, muscle and spleen.
Matrix Metalloproteinase 16 degrades various components of the extracellular matrix such as collagen type III andfibronectin and activates progelatinase A but has no effect on type I, II, IV and V collagen. It generates two kinds of transcript in which one encodes membrane-bound form and the soluble form of protein which are both activated by MMP2 through cleavage thus, caught up in remodeling of blood vessel matrix.
Matrix Metalloproteinase 16 is synthesized as active zymogen which is triggered by proteolytic action and plays a nonstop role in cleavage formation ofproteins in the cellular environment yet can indirectly functions via enzymatically activating protein form of other matrix.
Gene name: MMP16
Protein name: Matrix metalloproteinase-16