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From Biology-Online Dictionary
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1. To cultivate by manual labour; to till; hence, to develop by culture. To whom we gave the strand for to manure. (Surrey) Manure thyself then; to thyself be improved; And with vain, outward things be no more moved. (Donne)

2. To apply manure to; to enrich, as land, by the application of a fertilizing substance. The blood of english shall manure the ground. (Shak)

Origin: Contr, from OF. Manuvrer, manovrer, to work with the hand, to cultivate by manual labour, f. Manuvker. See manual, ure, opera, and cf. Inure.