Confused and have questions? We’ve got answers. With Chegg Study, you can get step-by-step solutions to your questions from an expert in the field. If you rather get 1:1 study help, try 30 minutes of free online tutoring with Chegg Tutors.

Lovastatin

From Biology-Online Dictionary | Biology-Online Dictionary
Jump to: navigation, search

Lovastatin

(Science: chemical) a fungal metabolite isolated from cultures of aspergillus terreus. The compound is a potent anticholesteraemic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme a reductase (hydroxymethylglutaryl coa reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. Several studies have shown that because of its enzyme inhibitory activity it acts as an antineoplastic agent for certain tumours.

Pharmacological action: anticholesteraemic agents, antineoplastic agent, hydroxymethylglutaryl-coa reductase inhibitors.

chemical name: butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-