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From Biology-Online Dictionary | Biology-Online Dictionary
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1. A water course or way; a reach of water. Down that long, dark lode . . . He and his brother skated home in triumph. (c. Kingsley)

2. (Science: chemical) a metallic vein; any regular vein or course, whether metallic or not.

Origin: as. Lad way, journey, fr. Lioan to go. See lead to guide, and cf. Load a burden.