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The process of breaking down of lipids (fats) into fatty acids and glycerol


Lipolysis is carried out via hydrolysis of lipids, e.g. triglycerides, into free fatty acids that are later degraded into acetyl units through beta oxidation.

Certain hormones, such as epinephrine, norepinephrine, testosterone, and cortisol, induce lipolysis. They activate 7TM receptors that in turn activate adenylate cyclase. The latter boosts cAMP levels, causing the activation of protein kinase A, which activates lipases. Lipase is an enzyme that speeds up the breakdown of lipids.

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