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Leukocyte inclusion

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noun, plural: leukocyte inclusions

Round or oval cytoplasmic inclusion of neutrophils containing remnants of rough endoplasmic reticulum, especially from the proganulocyte stage of cell development.


Leukocyte inclusions stain sky blue to grayish blue with Romanowsky stains and about 2 µm in diameter. They represent rapid turnover of cells and toxic granulation. They are commonly found in patients with infections, burns, trauma, pregnancy, or cancer.

Synonym: Dohle body, Dohle inclusion.
See also: Chediak-higashi disease.