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From Biology-Online Dictionary | Biology-Online Dictionary
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1. Literate; educated; versed in literature. Are you not lettered? The unlettered barbarians willingly accepted the aid of the lettered clergy, still chiefly of roman birth, to reduce to writing the institutes of their forefathers. (Milman)

2. Of or pertaining to learning or literature; learned. a lettered education.

3. Inscribed or stamped with letters.