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Lebers hereditary optic atrophy

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Lebers hereditary optic atrophy

hereditary degeneration of the optic nerve and papillomacular bundle with resulting rapid loss of central vision, progressive for several weeks, then usually stationary with permanent central scotoma; age of onset is variable, most often in the third decade; more males than females are affected and transmission is cytoplasmic and strictly on the female side. Mutation on the mitochondrial chromosome involved, which presumably interacts with an x-linked mutant. This mechanism may explain the bizarre sex ratio, which differs significantly from one country to another.