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Lead hydroxide stain

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Lead hydroxide stain

(Science: technique) a stain for electron microscopy; after aldehyde fixation, alkaline lead hydroxide preferentially stains rna, but after OsO4 fixation, it reacts largely with osmium in tissues to give a general stain; in addition to binding to cytomembranes, it also stains carbohydrates (e.g., glycogen).