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Layilin

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Definition

noun

A type I transmembrane protein that has an ability to mediate signals from extracellular matrix to the cytoskeleton of the cell.

Supplement

Layilin is newly cloned 55 kDa membrane binding colleague for talin that is extensively expressed in different cell types and tissue extracts and has 280-435 amino acids where it is generally located at the peripheral ruffles of spreading cells and is recruited to membrane ruffles in cells. It is then represents as membrane-binding sites that recruit talin to ruffles and is mapped on chromosome 11q23.1.

Layilin extracellular domain is homologous with the carbohydrates-recognition domains of C-type lectins. It functions in a way analogous to selectins in mediating transient interactions with extracellular matrix. It is also a key regulator of cytoskeleton plasma membrane interactions in polarized cells that involved in maintaining intercellularepithelial contact.

Layilin is a surface hyaluronan receptor with an extracellular domain that interacts with merlin, radixin and moesin family. Studies using microtiter plate binding assays, co-precipitation and staining techniques reveals that this protein is specifically binds to hyaluronan but not to other glycosaminoglycans. Hyaluronan, an omnipresent extracellular matrix component divulges a remarkable similarity between layilin and CD44 since both can bind to cytoskeleton-membrane linker proteins through their cytoplasmic domains.

Gene name: LAYN

Protein name: Layilin

See also:

Transmembrane

Transmembrane helix

Protein component