Lamin-B1

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Definition

noun

Intermediate filament proteins that make up the lattice-like matrix in the inner face of the nuclear membrane that lie behind the nuclear envelop.

Supplement

Lamin-B1 is a protein in humans that encoded three genes LMNA, LMNB1, and LMNB2 that extremely preserved throughout evolution. At some stage in mitosis lamina matrix is reversibly disband as the lamin protein is phosphorylated and measured to involve in nuclear stability, gene expression and chromatin structure. It is also phosphorylated within transcripts of engaging IgM surface receptor of resting splenic B cells.

Lamin-B1 is enormously helpful as nuclear loading controls with nuclear extracts since during cell apoptosis this protein is cleaved via caspases and removed from the nuclear if membrane is spun out. The affixing of chromatin to the nuclear lamina is drawn in the control ofgene expression and in DNA replication and repair.

Vertebrate lamins contains type A and B in which this gene encodes one of the two B type proteins that able to facilitate together with hetero-chromatin attached to the internal surface of thenuclear membrane by the lamin B receptor wherein the splicing fallout in transcript variants and doubling-up of this gene is linked with autosomal dominant adult-onset leukodystrophy.

Gene name: LMNB1

Protein name: Lamin-B1

See also:

Lamins

Apoptosis

Intermediate filaments