Kruppel-like factor 8
Kruppel-like factor 8 gene is mapped on chromosome Xp11.21 that contains 6 exons at C-terminal DNA binding domain with 3 zinc-fingers and consists of multiple transcript variants. It contains 359 amino acids with nuclear localization signals upstream of the zinc-fingers that affluent of hydrophobic valine present abundantly in heart, kidney and placenta but also detectable in other tissues.
Kruppel-like factor 8 has been pragmatic in several types of cancers like in bladder cancer in which reduced KLF8 significantly inhibit proliferation and colony formation as well as the reduction of vimentin andN-cadherin expression with an increase in beta-catenin thereby provides a potential therapeutic approach for gene therapy in bladder cancer.
Kruppel-like factor 8 is a binding protein that can recognize CACCC-box elements and repress gene region. It is very similar to KLF3 that recruits CtBP and rely on additional repression mechanisms since mutation contact motif in protein that does not completely abolish repression activity.
Gene name: KLF8
Protein name: Kruppel-like factor 8