Kruppel-like factor 3
Kruppel-like factor 3 gene mapped on chromosome 4p14 that contains 345 amino acids which highly expressed in the red blood cell lineage due to the presence of erythroid specific promoter driven by KLF1. It mainly repressed transcription through the transcriptional corepressor C-terminal binding protein that attributes zinc-finger domain but deficient in N-terminal button head box. It is also dependent on the sumoylation of its K10 and K197 within C-terminal resides three C2H2 zinc fingers that preferentially bind the site of NRG GNG NGR.
Kruppel-like factor 3 acts as a feedback repressor during erythropoiesis which is activated by KLF1 that binds alpha globin gene regulatory sequence during erythroid maturations in which lacking of KLF3 confers de-repression of alpha globin gene expression thereby contributes to the silencing of the alpha globin locus in non-erythroid tissues in which across the fibroblasts this gene does not occupy the promoter region of alpha globin instead binds to the DNase hypersensitive regions.
Kruppel-like factor 3 is involved in the regulation of adipogenesis wherein adipolin is significantly upregulated in the absence of KLF3 that binds to the Fam132 alpha promoter leads to repression of the activity, thus boosting the level of adipolin via targeting of KLF3 offers a novel potential therapeutic strategy for the treatment of insulin resistance.
Gene name: KLF3
Protein name: Krueppel-like factor 3