Kruppel-like factor 2
Kruppel-like factor 2 gene is mapped on chromosome 19p13.13-p13.11near to KLF1 with a molecular weight of 37kDa that turn on transcription by binding to the CACCC box in the beta-globin gene promoter. It appears to be needed for the normal valve formation together with its dependence on intracardiac hemodynamic forces thus, confirmed a critical role for reversing flows for the period of valvulogenesis and reveals subtle perturbations of normal hemodynamic patterns resulted in major alterations in gene expression and valve dysgenesis.
Kruppel-like factor 2 overexpression increasedblood clotting time as well as flow rate under basal and inflammatory conditions wherein it robustly induced thrombomodulin and endothelial nitric oxide synthase expression and reduced plasminogen activator inhibitor-1 thereby identified as a novel transcription regulator of endothelial thrombotic function.
Kruppel-like factor 2 is necessary for T-cell trafficking in which deficient in thymocytes show impaired expression of several receptors needed for thymocyte migration and peripheral trafficking together with the sphingosine-1-phosphate receptor and beta-7 integrin as a result, binds and transactivates the promoter for S1P1 crucial for thymocyte recirculation through peripheral lymphoid organs thus, serves to license mature T-cells for trafficking from the thymus and recirculation through lymphoid tissues.
Gene name: KLF2
Protein name: Kruppel-like factor 2