Kruppel-like factor 1
Kruppel-like factor 1 gene mapped on chromosome 19p13.2 that contains 3 exons which encodes a hematopoietic transcription factor that induces high level expression of beta-globin and other erythroid genes. It is an important embryonic erythropoiesis that directly binds positively to globin promoters. It contains 3 zinc-fingers and a proline that mostly expressed in bone marrow and erythroleukemic cell lines but not in myeloid or lymphoid cell lines.
Kruppel-like factor 1 gene encodes a necessary transcriptional activator that directs high-level expression of the adult beta-globin promoter as a result of binding to its CACCC element as well as for the BCAM protein expressed on erythroid cells.
Kruppel-like factor 1 mutations resulted in dominantly inheritedLutheran-negative In(Lu) red blood cell phenotype wherein study reveals that lack of expression of the Lu antigen results from the decreased transcription of erythroid-specific genes associated with red blood cell maturation. It is also associated in some diseases like anemia, a blood disorder characterized by ineffective erythropoiesis and hemolysis wherein circulation of erythroblasts shows various morphologic abnormalities.
Gene name: KLF1
Protein name: Kruppel-like factor 1