Kruppel-like factor 1

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Definition

noun

A zinc-finger protein that is responsible in hematopoietic transcription factors to stimulates high level expression of beta-globin.

Supplement

Kruppel-like factor 1 gene mapped on chromosome 19p13.2 that contains 3 exons which encodes a hematopoietic transcription factor that induces high level expression of beta-globin and other erythroid genes. It is an important embryonic erythropoiesis that directly binds positively to globin promoters. It contains 3 zinc-fingers and a proline that mostly expressed in bone marrow and erythroleukemic cell lines but not in myeloid or lymphoid cell lines.

Kruppel-like factor 1 gene encodes a necessary transcriptional activator that directs high-level expression of the adult beta-globin promoter as a result of binding to its CACCC element as well as for the BCAM protein expressed on erythroid cells.

Kruppel-like factor 1 mutations resulted in dominantly inheritedLutheran-negative In(Lu) red blood cell phenotype wherein study reveals that lack of expression of the Lu antigen results from the decreased transcription of erythroid-specific genes associated with red blood cell maturation. It is also associated in some diseases like anemia, a blood disorder characterized by ineffective erythropoiesis and hemolysis wherein circulation of erythroblasts shows various morphologic abnormalities.

Gene name: KLF1

Protein name: Kruppel-like factor 1

Synonyms:

CDAN4

EKLF

HBFQTL6

INLU

See also:

Transcription factor protein

Zinc finger protein