(Science: syndrome) congenital and familial disorder characterised by hypogonadotropic hypogonadism, eunuchoidal features, and anosmia or hyposmia. It is caused by a defect in the synthesis and/or release of lhrh (luteinizing hormone-releasing hormone; gonadorelin) from the hypothalamus as a result of faulty embryonic neuronal migration. The gene responsible for this is found in the region xp22.3 on the short arm of the x chromosome. There is a homolog on the y chromosome. The syndrome is more prevalent in males by a ratio of three to one.