Kallikrein 9 gene mapped on chromosome 19q13.41 that contains 5 exons in which it is regulated by steroid hormones in breast cancer cell line. It is involved in tumorigenesis and other disease conferring importance in growth and progression implicated in the development of the diseases.
Kallikrein 9 is differentially expressed in ovarian and breast cancer. Human plasma kallikrein is produced in the liver and circulates in the plasma hurdle to molecular weight as a free zymogen once activated by coagulation factor XII displays endopeptidase activity towards peptide bonds afterarginine and lysine and is also able to cleaved inactive precursor proteins to generate active products like prourokinase and plasminogen.
Gene name: KLK9
Protein name: Kallikrein-9