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Jean-Pierre Changeux

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A French neuroscientist and biochemist known for his research, e.g. the structure and function of allosteric proteins


Jean-Pierre Changeux is a French scientist that specializes in the field of neurosciences and biochemistry. One of his notable works is his research in the structure and function of proteins, especially the allosteric proteins. He is famous in the field of biochemistry for his proposed model showing the allosteric transitions of proteins made up of identical subunits called Monod-Wyman-Changeux model. This model is used to describe the allosteric transition of a protein between resting and tense states, stabilized by an agonist, an inhibitor and a substrate. Other known notable works are his research on the early development of the nervous system and cognitive function, the theory of epigenesis through synapse selection, and the identification and purification of the nicotinic acetylcholine receptor. His isolation of the nicotinic acetylcholine receptor is the first ever isolated membrane pharmacological receptor1 and his team was the firsts to describe the primary structure of the subunits of the receptor.2

See also:

1 Changeux J.-P., Kasai M., Huchet M., Meunier J.-C. (1970). Extraction à partir du tissu électrique de gymnote d'une protéine présentant plusieurs propriétés caractéristiques du récepteur physiologique de l'acétylcholine. C. R. Acad. Sci. 270D: 2864-2867.
1 Devillers-Thiéry A., Changeux J.-P., Paroutaud P., and Strosberg A.D. (1979). The amino-terminal sequence of the 40.000 molecular weight subunit of the acetylcholine receptor protein from Torpedo marmorata. FEBS Lett. 104: 99-105.