Janus kinase 1
Janus Kinase 1 is a member of new class protein tyrosine kinase characterized by the presence of second phosphotransferase domain that is mapped to chromosome 1p31.3. It is large and widely expressed membrane-associated phospho-protein of approximately 130,000 Da that bears conserved domain of 250-300 amino acids competent of phosphorylating substrate proteins on tyrosine residues.
Janus Kinase 1 plays a significant role in initiating responses to multiple major cytokine receptor families and is important in transducing a signal by IFN-α/β type I and IFN-γ type II interferon. Expression of Janus kinase 1in cancer cells permit individual cells to contact, allowing it to get away from tumor formation and metastasized to other part of the body.
Janus Kinase 1 involved in interferon-gamma pathway that mirrors the requirement of theses kinases in an exact assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins that acts as a unique family of transcriptions factors called STAT (signal transducers and activators of transcription).
Gene name: JAK1
Protein name: Tyrosine-protein kinase JAK1