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Isaacs syndrome

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Isaacs syndrome

(Science: syndrome) a rare sporadic disorder of unknown aetiology with onset usually in late childhood or early adulthood, characterised by intermittent or continuous involuntary Muscle contractions, producing stiffness or clumsiness and accompanied by increased sweating, increased skin temperature, fasciculations, and myokymia. If facial, pharyngeal, or laryngeal muscles are involved, dysphasia and respiratory obstruction can occur. Muscle abnormalities persist during sleep and general anaesthesia, but are blocked by curare, indicating site of lesion is peripheral nerve.