Interstitial fluid

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The fluid found in the intercellular spaces composed of water, amino acids, sugars, fatty acids, coenzymes, hormones, neurotransmitters, salts, and cellular products. It bathes and surrounds the cells of the body, and provides a means of delivering materials to the cells, intercellular communication, and removal of metabolic waste.


The interstitial fluid is the main component of the extracellular fluid (other components are plasma and transcellular fluid).

Word origin: L interstiti(um) interstice + -al

Related forms: interstitially (adverb).

Also called: tissue fluid, intercellular fluid.
Compare: extracellular fluid.