Interleukin-6 is a cytokine that contains a monomer of 184 amino acids produced by T-cells endothelial cells and macrophages mapped on chromosomes 7p15. It has various molecular forms wherein each molecule has a different function secreted by different cells in discrete situations activated through diverse stimuli.
Interleukin-6 is released in retort to infection, trauma, neoplasia and burns that role out in acute phase protein induction to B and T cell growth and differentiation wherein it excites the acute phase reaction that boosts the innate immune system and defend againsttissue injury thus resulted in the discharge of definite proteins into the blood plasma by liver cells and decrease the synthesis rate of the proteins.
Interleukin-6 has direct effects on cells where it intercede the property of other cytokines and interacts with glucocorticoid. It is also established in the resting normal T-cells, myeloid cell lines, and hepatoma cell lines, normal B-cells, myeloma cell lines and Epstein - Barr virus that upholds proliferation thereby, escort to the transcription of broad selection of proteins through all majortransduction pathways.
Gene name: IL6
Protein name: Interleukin-6(IL-6)
• Hepatocyte stimulating factor (HSF)
• interleukin-HP1 (IL-HP1)
• Monocyte-granulocyte inducer type 2 (MGI-2)
• Hybridoma growth factor (HGF)