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Interleukin-10

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Definition

noun

An anti-inflammatory cytokine found in humans that are programmed via the IL-10 gene which have the abilities to hold back the antigen production capacity of antigen presenting cells.

Supplement

Interleukin-10 also identified as cytokine synthesis inhibitory factor (CSIF) that are capable of reducing synthesis of pro-inflammatory cytokine such as TNF alpha, IFN gamma ,IL-2 and IL-3 by cell macrophages and regulatory T-cells yet it stimulates certain T-cells and mast cells as well as enhances the survival of B cell and antibody production.

Interleukin-10 contains 5 exons and a span of 5.2 kb of genomic DNA that are mainly formed by monocytes and lymphocytes. The expression of IL-10 is nominal on unmotivated tissues that require stimulating factor by commensal micro-flora where it strongly regulated by transcriptional and post-transcriptional point. It also involved in regulation of JAK-STAT signaling pathway and able to block NK-kB activity.

Interleukin-10 intervene immunostimulatory that helps to eradicate infectious and noninfectious materials with limited inflammation. It is also a prevailing tool of the central nervous system to avoid hyper inflammatory processes via activation of the neuro-endocrine axis after severe stress reactions. However a deficiency of IL-10 has been considered to show some patho-physiological relevance in inflammatory disorder typify by type 1 cytokine like psoriasis.

Acronym: IL-10

See also:

Interleukin

Cytokine