Interleukin-10 also identified as cytokine synthesis inhibitory factor (CSIF) that are capable of reducing synthesis of pro-inflammatory cytokine such as TNF alpha, IFN gamma ,IL-2 and IL-3 by cell macrophages and regulatory T-cells yet it stimulates certain T-cells and mast cells as well as enhances the survival of B cell and antibody production.
Interleukin-10 contains 5 exons and a span of 5.2 kb of genomic DNA that are mainly formed by monocytes and lymphocytes. The expression of IL-10 is nominal on unmotivated tissues that require stimulating factor by commensal micro-flora where it strongly regulated by transcriptional and post-transcriptional point. It also involved in regulation of JAK-STAT signaling pathway and able to block NK-kB activity.
Interleukin-10 intervene immunostimulatory that helps to eradicate infectious and noninfectious materials with limited inflammation. It is also a prevailing tool of the central nervous system to avoid hyper inflammatory processes via activation of the neuro-endocrine axis after severe stress reactions. However a deficiency of IL-10 has been considered to show some patho-physiological relevance in inflammatory disorder typify by type 1 cytokine like psoriasis.