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Interferon regulatory factor 2

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Definition

noun

A transcriptional suppressor of type I interferon regulatory transcription factors that is able to safeguard the renewal of multilineage differentiation capacity of hematopoietic stem cells.

Supplement

Interferon regulatory factor 2 gene mapped on chromosome 4q35.1 that specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. It also functions as activator of various genes including H4 and IL-7.

Interferon regulatory factor 2 is implicated in cell cycle regulation during binding the site II promoter region of H4 and stimulates transcription during cell growth however the overlapping recognition sequence jointly modulates the H4 gene transcription level in an order of magnitude thereby, the amalgamated organization of site II supports responsiveness to multiplesignaling pathways modulating the activities of H4 gene expression in cells andtissues with unique phenotypic transcription factor during cell cycle.

Interferon regulatory factor 2 acetylated by p300 and PCAF wherein Lys-75 and Lys-78 are the major acetylation sites in which during acetylation do not alter the DNA binding site activity in which IRF-2 interacted with p300 bound to the endogenous H4 promoter only on growing cells thus, signifies that acetylated IRF-2 in cell growth-dependent behavior enables to contribute to the transcription of cell growth-regulated promoters.

Gene name: IRF2

Protein name: Interferon regulatory factor 2

See also:

Interferon regulatory protein

Cell cycle