Integrin alpha-1 links with beta-1 chain to outline hetero-dimer that functions as dual laminin-collagen receptor in neural cells and hematopoietic cells. It has 206 amino acids in its N-terminal followed by 3 divalent cation binding sites in C-terminal transmembrane domain which also has 28 N-glycosylation sites.
Integrin alpha-1 mixed up in the early remodeling of osteoarthritic cartilage and has a vital role in the regulation of mesenchyma stem cell proliferation and cartilage production. The alpha 1 subunit holds an inserted Von Willebrand factor type I domain which considered to be implicated in collagen binding.
Integrin alpha-1 gene located inchromosome 5q11.2 that encodes integrin alpha chain protein which formed heterodimer thereby participating in an array of cell to cell interactions to facilitate cell migration, tissue and organ development and differentiation as a consequence, plays an important functions in inflammation and fibrosis.
Gene name: ITGA1
Protein name: Integrin alpha-1