Integrin Alpha-M gene is mapped on chromosome 16p11.2 with a molecular weight of 155 to 165 kD that complement receptor type 3lymphocyte function-associated antigens. It share a common beta chain of 94 kD linked covalently to 1 of 3 alpha chains. It has high expression in effector cells of the immune system involved in various processes that regulates inflammation and immunity like leukocyte adhesion,activation, phagocytosis, degranulation, migration, apoptosis and superoxide release.
Integrin Alpha-M implicated in several adhesive interactions and is identical with CR-3, a receptor for the iC3b fragment as well as a receptor for fibrinogen, factor X andICAM1 that recognizes the R-G-D peptide in C3b and P1-P2 peptides of fibrinogen gamma chain. It is also essential in clot dissolution, blood coagulation and regulation of body mass.
Integrin Alpha-M involved in the initiation and progression of atherosclerosis and vascular repair after mechanical arterial injury in which leukocytes is recruited as a precursor to intimal thickening thereby markers of leukocytes activation increased expression of integrin alpha-M that is responsible for firm leukocytes adhesion to platelets and fibrinogen on uncovered vessels thus, absence of this glycoprotein damaged transplatelet leukocytes movement into the vessel wall sinking leukocyte accumulation.
Gene name: ITGAM
Protein name: Integrin alpha-M