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Inosine monophosphate

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(biochemistry) A nucleoside monophosphate found in muscles and other tissues


Inosine monophosphate (IMP) is a nucleotide, particularly a nucleoside monophosphate. It is commercially used as a flavor enhancer. It occurs in muscles and other tissues but often it is obtained from meat industry waste and chicken byproducts.

Biochemically, inosine monophosphate is the first nucleotide formed during purine synthesis. It is produced by the deamination of adenosine monophosphate (AMP).1 IMP is a precursor to AMP and guanosine monophosphate (GMP). Thus, in purine biosynthesis, it represents a branching point. Both metabolic pathways (i.e. one leading to AMP formation and the other, GMP) would require energy. The pathway leading to the formation of AMP is energized by (guanosine triphosphate) GTP whereas the pathway leading to the formation of GMP would utilize energy in the form of adenosine triphosphate (ATP). An excess of GTP would result in the increased synthesis of AMP whereas an excess of ATP would increase the synthesis of GMP.2

IUPAC name: 5'-Inosinic acid

Chemical formula: C10H13N4O8P


  • IMP


  • inosinic acid
  • Hypoxanthine ribotide
  • inosine phosphate

See also:

1 "Inosinic acid". Retrieved from [[1]].
2 Purine Nucleotide Biosynthesis. (2016). The Medical Biochemistry Page (Online). Retrieved from [[2]].