Hyaluronidase 2 gene mapped on chromosome 3p21.31that contains a molecular mass of 20kDa with an N-terminal signalpeptide expressed in all tissues except in adultbrain. It is specifically located in thelysosomes that shown to have hyaluronidase activity below pH 4.0. It is a glycosylphosphatidylinositol anchored protein on the cell surface that acts as a receptor for entrance into the cell. Moreover, leaving the hyaluronidase 2 on cell facades resulted in the transport of lysosomes for degradation.
Hyaluronidase 2 hydrolyzes high molecular weight of hyaluronic acid to produce an intermediate-sized product to give small oligosaccharides. It is involved in signal transduction and mitogenic responses mediated oncogenesis. In lung cancer, identification of hyaluronidase 2 receptor provides tools for further investigation of the mechanism on oncogenesis and its relationship to bronchiolo-alveolar carcinoma.
Hyaluronidase 2 is implicated in the decrease ofhydration and architectural support of skin aging caused by genetic and environmental factors via downregulation of hyaluronic acid during photoaging wherein UV-B irradiation induces differential regulations of hyaluronidase expression and enzymatic activity in keratinocyte thereby confers to contribute the cutaneous photoaging.
Gene name: HYAL2
Protein name: Hyaluronidase-2