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From Biology-Online Dictionary
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1. Destitute of hope; having no expectation of good; despairing. I am a woman, friendless, hopeless. (Shak)

2. Giving no ground of hope; promising nothing desirable; desperate; as, a hopeless cause. The hopelessword of never to return breathe i against thee, upon pain of life. (Shak)

3. Unhoped for; despaired of. Hopelessly, Hopelessness.