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Holt-oram syndrome

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Holt-oram syndrome

(Science: syndrome) An inherited type of heart disease where there are defects in the internal walls (septa) between the atrium and ventricle chambers of the heart.

holt-oram syndrome is dominant (requires only one copy in the genome to be expressed) and is often associated with skeletal deformities such as abnormally short forearms or thumbs.

Inheritance: autosomal dominant.