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Heat-shock genes

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Heat-shock gene

(Science: molecular biology) a set of genes present in most animals which are transcribed suddenly, quickly, and with coordination when the animal is exposed to certain types of stress such as a sudden temperature increase.

The response is mediated by heat shock transcription factor (HSF), which is present in a monomeric, non-DNA binding form is unstressed cells and is activated by stress to a tromeric form which can bind to promoters of heat shock genes.