Haemophilus ducreyi has a circular chromosome with a sized at about 1.5 micrometer long and 0.5 micrometer wide arrange on chain which cannot synthesize heme due to its deficiency of enzymes ferro-chelatase that used to catalyze heme synthesis through putting iron into protoporphyrin IX, therefore its main source of heme is from hemoglobin acquired from host cell invasion.
Haemophilus ducreyi infects host cell by entering the wounds and stimulating keratinocytes, endothelial cells, fibroblast and melanocytes that secretes IL-8. This bacterium transport from lesions yet can also be transferred prior to the lesion. It is normally grows on male genitalia that causes sore ulcer at the infection area while female is rarely affected.
Haemophilus ducreyi linked as the primary cause of Chancroid disease and infection of this bacterium increases the likelihood of acquiring HIV since coinfection is necessary to distinguish due to the reaction of antibiotic therapy is less effective for Chancroid patients with AIDS compared to patients without AIDS.
Class: Gamma Proteobacteria
Species: Haemophilus ducreyi