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From Biology-Online Dictionary | Biology-Online Dictionary
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1. Sullen malice or malevolence; cherished malice, enmity, or dislike; ill will; an old cause of hatred or quarrel. Esau had conceived a mortal grudge and eumity against hie brother Jacob. (South) The feeling may not be envy; it may not be imbittered by a grudge. (i. Taylor)

2. Slight symptom of disease. Our shaken monarchy, that now lies . . . Struggling againat the grudges of more dreaded calamities. (Milton)

Synonym: pique, aversion, dislike, ill will, hatred, spite. See pique.