A type of sphingolipidosis that is often caused by a deficiency in α-galactosidase A resulting in the accumulation of glycolipids, particularly ceramide trihexoside, in the endothelial cells in blood vessel walls
Farby disease is a metabolic disorder that is caused by the accumulation of glycolipids, particularly ceramide trihexoside, in the lysosomes of the endothelial cells in blood vessel walls. The accumulation is due to a deficiency of a functional α-galactosidase A. This enzyme is a glycoside hydrolase that hydrolyses the terminal alpha-galactosyl moieties from the glycolipids and the glycoproteins. The deficiency of this enzyme may be attributed to a mutation in the gene encoding it (i.e.GLA gene). Farby disease may be inherited as an X-linked trait. Thus, the symptoms of Farby disease are more pronounced among men that bear a copy of the defective gene. The symptoms in women may vary from having no symptoms to having severe symptoms.
The disease is named after Johannes Fabry, a German dermatologist, who first described it in 1898. He called the disease purpura haemorrhagica nodularis based on the dermatological features of the disease on a 13-year-old boy.
- alpha-galactosidase A deficiency
- Anderson-Fabry disease
- angiokeratoma corporis diffusum
- diffuse angiokeratoma
- glycolipid lipidosis
- Ruiter-Pompen disease
- Sweeley-Klionsky disease