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Acronym for Golgi - Endoplasmic Reticulum - Lysosome complex, a system found in the cell that involves golgi apparatus, endoplasmic reticulum and lysosomes mainly to perform endocytosis and exocytosis functions


The GERL is a complex comprised of organelles, particularly Golgi apparatus, endoplasmic reticulum, and lysosome. These organelles form a system to carry out the following cellular processes:

The Golgi apparatus is the organelle referred to as the package center of the cell since its main function is to package molecules for secretion. It sorts out the proteins secreted by the endoplasmic reticulum into packages to be sent to the appropriate destination. The Golgi apparatus may modify the protein by adding sugar to produce glycoprotein through glycosylation. The glycoprotein that is bound to be transported outside the cell will be excreted as vesicles. If the glycoprotein is for later use, it may be stored in vesicles within the cell (as lysosomes).

The endoplasmic reticulum is a network of flattened sacs in which the membranes are connected to the nuclear membrane. There are two types of endoplasmic reticulum, i.e. rough (RER) and smooth (SER). The RER is involved in protein synthesis and secretion whereas the SER is involved in lipid synthesis, drug detoxification, intracellular transport, etc.

The lysosome is an organelle with a wide range of digestive enzymes. The digestive enzymes are used mainly for the digestion and removal of excess or worn-out organelles, food particles, and engulfed viruses or bacteria.

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