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Gap protein

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Gap protein --> GTPase activating protein

(Science: molecular biology) Originally purified as a 125 kd protein from bovine brain (1044 amino acids), stimulates the GTPase activity of ras p21 and thereby switches it to the inactive state.

gap may itself be regulated by phospholipids and by phosphorylation on a tyrosine residue by growth factor receptors (pdgf R, egf R). The neurofibromatosis type 1 gene NF1) codes for a protein homologous to gap. Gap has both SH2 and SH3 domains. Another example is sar 1 (from yeast).